Trailing 1-0 since the third inning, Boston tied the game in the eighth on Dustin Pedroia's first home run since May 10, a one-out blast to left field off Seattle starter Jason Vargas.
After the Mariners, who beat the Red Sox twice in walk-off fashion in this series, stranded the winning run at second base in the ninth, Kalish, a pinch- hitter, ripped a one-out double off the right-field wall in the 10th.
Pedroia then singled off Brandon League (0-5) before he was replaced by southpaw Lucas Luetge. Brought in to face the left-handed swinging Ortiz, Luetge fell behind 2-0 in the count before Ortiz lofted a fly ball to deep right field, enabling Kalish to trot home for a 2-1 Boston lead.
Alfredo Aceves picked up his 19th save of the season with a five-pitch 1-2-3 10th. Vicente Padilla (2-0) earned the win after working out of trouble in the ninth.
Boston starter Felix Doubront allowed one run on three hits and walked five in 4 1/3 innings.
Vargas hurled eight strong innings, with Pedroia's homer one of five hits given up the left-hander. Third baseman Kyle Seager made a diving catch, snagging a line drive off the bat of Nick Punto, to help Vargas escape a bases-loaded jam in the second.
The Mariners got on the board in the third. Chone Figgins and Brendan Ryan hit back-to-back singles to open the inning, placing men on the corners after Figgins stole second. Ichiro Suzuki followed with a sacrifice fly to left field.
Seattle loaded the bases with one out two innings later, but Matt Albers got Jesus Montero to ground into a 5-3 double play.
Game Notes
Boston third baseman Will Middlebrooks left the game in the ninth with left hamstring tightness.Ortiz was elected by the fans as the starting designated hitter for the American League in the 2012 All-Star Game. Seattle right-hander Felix Hernandez also was named to the AL roster..Red Sox first baseman Adrian Gonzalez went 1-for-5 to extend his hitting streak to 12 games.The Mariners placed pitcher Erasmo Ramirez on the 15-day disabled list Sunday with a right elbow flexor strain, selected the contract of pitcher Josh Kinney from Triple-A Tacoma and designated catcher Adam Moore for assignment.
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